Interleukin 17 Receptor A Modulates Monocyte Subsets and Macrophage Generation In Vivo

Interleukin 17 Receptor A Modulates Monocyte Subsets and Macrophage Generation In Vivo

Interleukin (IL)-17A signaling via Interleukin 17 receptor A (Il17ra) contributes to the inflammatory host response by inducing recruitment of innate immune cells, but also plays a role in homeostatic neutrophilic granulocyte regulation. Monocytes, the other main innate immune cell, have a longer life span and can pursue multiple differentiation pathways towards tissue macrophages. Monocytes ar...

Expression of interleukin-6 receptor subunits in human macrophage subsets.

interleukin 17 receptor gene polymorphism in periimplantitis and chronic periodontitis.

gene polymorphism of cytokines influencing their function has been known as a contributing factor in the pathogenesis of inflammatory diseases of the tooth and implant supporting tissues. the aim of this study was to investigate the association of il-17r gene polymorphism (rs879576) with chronic periodontitis and periimplantitis in an iranian population. 73 patients with chronic periodontitis, ...

Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis.

Monocytes and macrophages play active roles in atherosclerosis, a chronic inflammatory disease that is a leading cause of death in the developed world. The prevailing paradigm states that, during human atherogenesis, monocytes accumulate in the arterial intima and differentiate into macrophages, which then ingest oxidized lipoproteins, secrete a diverse array of proinflammatory mediators, and e...

Activation In Vivo Monocyte Numbers and Macrophage Fas Death Receptor Signaling Represses